Monoclonal Antibody Seeds
Phage display based
We are collaborating with MorphoSys AG who is famous for their promising technology called HuCAL® (Human Combinatorial Antibody Library). Now we are developing our own unique therapeutic antibodies derived from HuCAL through the collaboration with Japanese Academia.
| Target | Indication | Stage | ||
|---|---|---|---|---|
| GFC101 | CD69 | Inflammatory diseases (Asthma, COPD, Colitis, RA, etc.) |
Pre-clinical | Detail |
| GFC201 | ADAM28 | Oncology (Breast, Lung cancers) |
Pre-clinical | Detail |
| GFC301 | ADAMTS4 | Arthritis (RA, OA) |
R&D | Detail |
New Biologics Seeds
PUREfrex® RD based
Natural amino acid based cyclic peptides were generated with PUREfrex® RD, and utilized for further development as a hit for peptide drug, or fused with existing biologics such as IgG or domain antibody for high functionalization.
Cyclic Peptides projects <Detail>
| No. | Target | Stage |
|---|---|---|
| No.1 | CTLA-4 (inhibitor) | Lead optimization |
| No.2 | Her2 | Lead optimization |
| No.3 | EGFR | Lead optimization |
| No.4 | Erk2 | Lead optimization |
| No.5 | IL-6 (inhibitor) | Lead optimization |
| No.6 | TNF-α | Under screening |
| No.7 | Herceptin | Hit identification for Mimotope |
New Biologics projects <Detail>
| No. | Construct | Stage |
|---|---|---|
| No.1 | anti-CTLA-4 pep / anti-PD-1 dAb | Lead optimization |
| No.2 | anti-Her2 pep / anti-Her2 dAb | Under construction |
| No.3 | anti-IL-6 pep / anti-TNF-α dAb | Under construction |
| No.4 | anti-Erk2 pep / GFP | Available for R&D (Imaging tool) |
(dAb: domain antibody)
Small molecule projects <Detail>
| No. | Target | Stage |
|---|---|---|
| No.1 | CTLA-4 | Hit identification |
| No.2 | IL-6 | Under construction |
